A hypothesis to explain why translation inhibitors stabilize mRNAs in mammalian cells: mRNA stability and mitosis.

@article{Ross1997AHT,
  title={A hypothesis to explain why translation inhibitors stabilize mRNAs in mammalian cells: mRNA stability and mitosis.},
  author={Jeff S Ross},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={1997},
  volume={19 6},
  pages={527-9}
}
  • Jeff S Ross
  • Published 1997 in
    BioEssays : news and reviews in molecular…
Protein synthesis inhibitors prolong the half-lives of most mRNAs at least fourfold in the somatic cells of higher eukaryotes and in yeast cells. Some mRNAs are stabilized because the inhibitors affect mRNA-specific regulatory factors; however, hundreds or thousands of other mRNAs are probably stabilized by a common mechanism. We propose that mRNA stabilization in cells treated with a translation inhibitor reflects a physiological process that occurs during each mitosis and is important for… CONTINUE READING

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