A hypothesis of thyroid-catecholamine-receptor interaction. Its relevance to affective illness.

@article{Whybrow1981AHO,
  title={A hypothesis of thyroid-catecholamine-receptor interaction. Its relevance to affective illness.},
  author={Peter C. Whybrow and Arthur J. Prange},
  journal={Archives of general psychiatry},
  year={1981},
  volume={38 1},
  pages={106-13}
}
Recent prospective studies suggest that thyroid state plays a role in affective disorders. A lack of thyroid hormones can lower the threshold for depression; an excess can contribute to a state of tense dysphoria. Thyroid function in some persons also appears to influence the course of affective disorders. Adequate mobilization of thyroid hormones favors recovery from depression; excess mobilization increases the risk of mania in vulnerable individuals. Although other mechanisms may be involved… CONTINUE READING
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