A hypothesis of haemolysis in haemolytic anaemias associated with enzymopathies.

A feature of a previously proposed mechanism of erythrocyte shape control is a control of the shape by the Donnan equilibrium ratio. An enzymopathy of the glycolytic pathway and nucleotide metabolism could alter the Donnan ratio, since it alters levels of phosphate intermediates and of end-products carbonic gas (CO(2)) and ammonia gas (NH(3)) which are… CONTINUE READING