A hypothesis of couplet molecules and couplet cells in gastric function and an association with Helicobacter pylori


BACKGROUND Gastrin, from G-cells, and histamine, from enterochromaffin-like (ECL) cells, are two of the hormones that regulate gastric activity. DISCUSSION It is proposed that the G-cells and the ECL cells are coupled by the couplet molecules gastrin and histamine and by a prior asymmetrical cell division. The gastrin (from G-cells) stimulates the ECL… (More)
DOI: 10.1186/s12876-016-0429-0


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