A hypothesis for the initiation of COPD.

  title={A hypothesis for the initiation of COPD.},
  author={Eleni G. Tzortzaki and Nikolaos Siafakas},
  journal={The European respiratory journal},
  volume={34 2},
Chronic obstructive pulmonary disease (COPD) is generally thought to depend on an aberrant immune response to a noxious or infectious agent, which may cause chronic inflammation. However, the initiation of this abnormal response is not fully understood. Here, we propose a new hypothesis for the beginning of COPD, that the immune response to inhaled agents, mainly cigarette smoke, is directed toward the airway epithelium, due to oxidative DNA damage of the lung epithelial barrier cells (LEBCs… CONTINUE READING
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