A hypothesis for how non-REM sleep might promote seizures in partial epilepsies: a transcranial magnetic stimulation study.

@article{Salih2007AHF,
  title={A hypothesis for how non-REM sleep might promote seizures in partial epilepsies: a transcranial magnetic stimulation study.},
  author={Farid Salih and Ramin Khatami and Saskia Marie Steinheimer and Rebekka Kretz and B. Schmitz and Pascal A Grosse},
  journal={Epilepsia},
  year={2007},
  volume={48 8},
  pages={1538-42}
}
PURPOSE To investigate alterations of inhibitory and excitatory cortical circuits during non-rapid eye movement (NREM) sleep in drug-naive patients with partial epilepsies and sleep-bound seizures only. METHODS A paired-pulse TMS paradigm was used to test intracortical inhibition (ICI) and facilitation (ICF) in the hemisphere of the epileptic focus in three untreated patients with nonlesional, nongenetic frontal lobe epilepsy in NREM2 (three patients), NREM3/4 (one patient), and wakefulness… CONTINUE READING