A hypothesis about how to achieve anticoagulation without bleeding.


The hypothesis is set forth that a prothrombotic state is frequently caused by epinephrine-activated platelets initiating the intrinsic coagulation cascade by binding factor XII, a pathway which is enhanced by stasis. This pathway explains spontaneous non-injury related thrombosis in atrial fibrillation on the arterial side of the circulation and deep vein… (More)
DOI: 10.1016/j.mehy.2015.10.021


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