A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer.

@article{Rosenberg1991AHN,
  title={A hypothesis: nonsteroidal anti-inflammatory drugs reduce the incidence of large-bowel cancer.},
  author={Lynn A Rosenberg and J R Palmer and Ann Graham Zauber and M. Ellen Warshauer and Paul D. Stolley and Samuel Shapiro},
  journal={Journal of the National Cancer Institute},
  year={1991},
  volume={83 5},
  pages={355-8}
}
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit prostaglandin synthesis and tumor growth in the rodent colon. We assessed NSAID use in relation to risk of human large-bowel cancer in a hospital-based, case-control study of 1326 patients with colorectal cancer and 4891 control patients. For regular NSAID use that continued into the year before interview, the multivariate relative risk estimate was 0.5 (95% confidence interval, 0.4 to 0.8); the estimate decreased as the duration of use… CONTINUE READING

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