A hypomorphic Cbx3 allele causes prenatal growth restriction and perinatal energy homeostasis defects

@article{Aydin2015AHC,
  title={A hypomorphic Cbx3 allele causes prenatal growth restriction and perinatal energy homeostasis defects},
  author={E. Aydin and D. Kloos and E. Gay and Willem Jonker and Lijuan Hu and J. Bullwinkel and Jeremy P. Brown and M. Manukyan and M. Giera and Prim B. Singh and R. Fundele},
  journal={Journal of Biosciences},
  year={2015},
  volume={40},
  pages={325-338}
}
ABSTRACTMammals have three HP1 protein isotypes HP1β (CBX1), HP1γ (CBX3) and HP1α (CBX5) that are encoded by the corresponding genes Cbx1, Cbx3 and Cbx5. Recent work has shown that reduction of CBX3 protein in homozygotes for a hypomorphic allele (Cbx3hypo) causes a severe postnatal mortality with around 99% of the homozygotes dying before weaning. It is not known what the causes of the postnatal mortality are. Here we show that Cbx3hypo/hypo conceptuses are significantly reduced in size and… Expand

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