A hyperthermostable bacterial histone-like protein as an efficient mediator for transfection of eukaryotic cells

@article{Esser2000AHB,
  title={A hyperthermostable bacterial histone-like protein as an efficient mediator for transfection of eukaryotic cells},
  author={Dirk Esser and Hiroshi Amanuma and Atsushi Yoshiki and Moriaki Kusakabe and Rainer Rudolph and Gerald E. Boehm},
  journal={Nature Biotechnology},
  year={2000},
  volume={18},
  pages={1211-1213}
}
Gene delivery has shown potential in a variety of applications, including basic research, therapies for inborn genetic defects, cancer, AIDS, tissue engineering, and vaccination. Most available systems have serious drawbacks, such as safety hazards, inefficiency under in vivo–like conditions, and expensive production. When using naked DNA, for instance, a large amount of ultrapure DNA has to be applied as a result of degradation by nucleases. Similarly, the use of eukaryotic histones, synthetic… CONTINUE READING

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