A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

@article{Reynaud1987AHM,
  title={A hyperconversion mechanism generates the chicken light chain preimmune repertoire.},
  author={C. Reynaud and Viviane Anquez and H. Grimal and J. C. Weill},
  journal={Cell},
  year={1987},
  volume={48 3},
  pages={379-88}
}
The chicken immunoglobulin light chain repertoire has been shown to be entirely derived from a single V lambda 1-J rearranged combination. The complete coding information of the lambda locus was determined: it comprises 25 V-hybridizing elements, all of which are pseudogenes, clustered in both orientations within 19 kb of DNA, starting 2.4 kb upstream of the V lambda 1 gene. Sequences of somatically rearranged V lambda 1 genes from embryonic and posthatching bursal cells show that… CONTINUE READING
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