A hydrophilic polymer grafted with a histone tail peptide as an artificial gene regulator.

@article{Shiosaki2011AHP,
  title={A hydrophilic polymer grafted with a histone tail peptide as an artificial gene regulator.},
  author={Shujiro Shiosaki and Masanori Kuramoto and Riki Toita and Takeshi Mori and Takuro Niidome and Yoshiki Katayama},
  journal={Bioorganic & medicinal chemistry},
  year={2011},
  volume={19 13},
  pages={
          4101-5
        }
}
In chromatin, gene transcription is regulated through posttranslational modifications on the histone N-terminal tail sequences, typically an acetyl group modification on lysine residues. To realize a simple model of the gene regulation of chromatin, we designed a hydrophilic polymer grafted with histone H3 tail peptides. The polyplex formed from the polymer and DNA suppressed the gene expression effectively although the polyplex was weaker than the polyplex of poly-L-lysine and DNA. This weaker… CONTINUE READING