A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent.

@article{Lippert2011AHP,
  title={A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent.},
  author={Alexander R Lippert and Kayvan R. Keshari and John Kurhanewicz and Christopher J Chang},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 11},
  pages={3776-9}
}
We report a new reaction-based approach for the detection of hydrogen peroxide (H(2)O(2)) using hyperpolarized (13)C magnetic resonance imaging ((13)C MRI) and the H(2)O(2)-mediated oxidation of α-ketoacids to carboxylic acids. (13)C-Benzoylformic acid reacts selectively with H(2)O(2) over other reactive oxygen species to generate (13)C-benzoic acid and can be hyperpolarized using dynamic nuclear polarization, providing a method for dual-frequency detection of H(2)O(2). Phantom images collected… CONTINUE READING
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