• Chemistry, Medicine
  • Published in
    The Journal of biological…
    1984

A hybrid superoxide dismutase containing both functional iron and manganese.

@article{Clare1984AHS,
  title={A hybrid superoxide dismutase containing both functional iron and manganese.},
  author={Debra A. Clare and Jochanan Blum and Irwin Fridovich},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 9},
  pages={
          5932-6
        }
}
A hybrid superoxide dismutase containing functional Mn and Fe has been isolated from Escherichia coli. Streptomycin, which binds tightly to both the Mn- and the Fe-containing superoxide dismutases, had the expected effect on the electrophoretic and chromatographic behavior of the hybrid. Treatment of the hybrid with H2O2, which selectively inactivates the Fe-containing enzyme, resulted in partial inactivation accompanied by a resegregation of subunits, with the formation of active Mn-enzyme and… CONTINUE READING

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