A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival

Abstract

Polyketides and nonribosomal peptides are two important types of natural products that are produced by many species of bacteria and fungi but are exceedingly rare in metazoans. Here, we elucidate the structure of a hybrid polyketide-nonribosomal peptide from Caenorhabditis elegans that is produced in the canal-associated neurons (CANs) and promotes survival during starvation-induced larval arrest. Our results uncover a novel mechanism by which animals respond to nutrient fluctuations to extend survival.

DOI: 10.1038/nchembio.2144

2 Figures and Tables

Cite this paper

@inproceedings{Shou2016AHP, title={A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival}, author={Qingyao Shou and Likui Feng and Yaoling Long and Jungsoo Han and Joshawna K. Nunnery and David H. Powell and Rebecca A Butcher}, booktitle={Nature chemical biology}, year={2016} }