A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

@article{Hatzi2013AHM,
  title={A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.},
  author={Katerina Hatzi and Yanwen Jiang and Chuanxin Huang and Francine E. Garrett-Bakelman and Micah D Gearhart and Eugenia G. Giannopoulou and Paul Zumbo and Kevin N. Kirouac and Srividya Bhaskara and Jose Mari Polo and Matthias Kormaksson and Alexander D MacKerell and Fengtian Xue and Christopher E. Mason and Scott W. Hiebert and Gilbert G. Priv{\'e} and Leandro Carlos Cerchietti and Vivian J. Bardwell and Olivier Elemento and Ari Melnick},
  journal={Cell reports},
  year={2013},
  volume={4 3},
  pages={578-88}
}
The BCL6 transcriptional repressor is required for the development of germinal center (GC) B cells and diffuse large B cell lymphomas (DLBCLs). Although BCL6 can recruit multiple corepressors, its transcriptional repression mechanism of action in normal and malignant B cells is unknown. We find that in B cells, BCL6 mostly functions through two independent mechanisms that are collectively essential to GC formation and DLBCL, both mediated through its N-terminal BTB domain. These are (1) the… CONTINUE READING