A hybrid bioreactor for high density cultivation of plant cell suspensions

  title={A hybrid bioreactor for high density cultivation of plant cell suspensions},
  author={Dong-Il Kim and Gyu Heon Cho and Henrik Pedersen and C N Chin},
  journal={Applied Microbiology and Biotechnology},
A hybrid bioreactor was developed for the production of secondary metabolites from high density cultivation of plant cell suspensions. Some of the advantages of both air-lift and cell-lift by agitation were combined. The addition of a decanting column also made it possble to run a perfusion system for high density culture or to run a two-stage culture efficiently. Cell growth and the production of berberine from Thalictrum rugosum in the hybrid bioreactor are reported in this paper. A cell… CONTINUE READING

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