A hyaluronan synthase suppressor, 4‐methylumbelliferone, inhibits liver metastasis of melanoma cells

@article{Yoshihara2005AHS,
  title={A hyaluronan synthase suppressor, 4‐methylumbelliferone, inhibits liver metastasis of melanoma cells},
  author={Shuichi Yoshihara and Atsushi Kon and Daisuke Kudo and Hideaki Nakazawa and Ikuko Kakizaki and Mutsuo Sasaki and Masahiko Endo and Keiichi Takagaki},
  journal={FEBS Letters},
  year={2005},
  volume={579}
}
4‐Methylumbelliferone (MU) inhibits the cell surface hyaluronan (HA) formation, and that such inhibition results in suppression of adhesion and locomotion of cultured melanoma cells. Here, we examine the effect of MU on melanoma cell metastasis in vivo. MU‐treated melanoma cells showed both decreased cell surface HA formation and suppression of liver metastasis after injection into the mice. Oral administration of MU to mice decreased tissue HA content. These HA knock‐down mice displayed… Expand
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