A humanized system for pharmacologic control of gene expression

@article{Rivera1996AHS,
  title={A humanized system for pharmacologic control of gene expression},
  author={Victor M. Rivera and Tim Clackson and Sridaran Natesan and Roy M. Pollock and Jane F. Amara and Terence P. Keenan and Shannon R. Magari and Tom Phillips and Nancy L. Courage and Franklin Cerasoli and Dennis A. Holt and Michael Z. Gilman},
  journal={Nature Medicine},
  year={1996},
  volume={2},
  pages={1028-1032}
}
Gene therapy was originally conceived as a medical intervention to replace or correct defective genes in patients with inherited disorders. However, it may have much broader potential as an alternative delivery platform for protein therapeutics, such as cytokines, hormones, antibodies and novel engineered proteins. One key technical barrier to the widespread implementation of this form of therapy is the need for precise control over the level of protein production. A suitable system for… 

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