A humanized murine monoclonal antibody protects mice either before or after challenge with virulent Venezuelan equine encephalomyelitis virus.

@article{Hunt2006AHM,
  title={A humanized murine monoclonal antibody protects mice either before or after challenge with virulent Venezuelan equine encephalomyelitis virus.},
  author={Ann R. Hunt and Shana Frederickson and Christopher Hinkel and Katherine S. Bowdish and John T. Roehrig},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 9},
  pages={2467-76}
}
A humanized monoclonal antibody (mAb) has been developed and its potential to protect from or cure a Venezuelan equine encephalomyelitis virus (VEEV) infection was evaluated. The VEEV-neutralizing, protective murine mAb 3B4C-4 was humanized using combinatorial antibody libraries and phage-display technology. Humanized VEEV-binding Fabs were evaluated for virus-neutralizing capacity, then selected Fabs were converted to whole immunoglobulin (Ig) G1, and stable cell lines were generated. The… CONTINUE READING

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