A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease.

@article{Washburn2011AHM,
  title={A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease.},
  author={Michael L. Washburn and Moses T. Bility and Liguo Zhang and Grigoriy I. Kovalev and Adam Buntzman and Jeffery A Frelinger and Walter T. Barry and Alexander Ploss and Charles M. Rice and Lishan Su},
  journal={Gastroenterology},
  year={2011},
  volume={140 4},
  pages={1334-44}
}
BACKGROUND & AIMS Studies of hepatitis C virus (HCV) infection, immunopathogenesis, and resulting liver diseases have been hampered by the lack of a small animal model. We developed humanized mice with human immune system and liver tissues to improve the studies of hepatitis C virus pathogenesis and treatment. METHODS To promote engraftment of human hepatocytes, we expressed a fusion protein of the FK506 binding protein (FKBP) and caspase 8 under control of the albumin promoter (AFC8), which… CONTINUE READING

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