A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells.

@article{SellierLeclerc2007AHM,
  title={A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells.},
  author={Anne-Laure Sellier-Leclerc and Arnaud Duval and St{\'e}phanie Riveron and M S Macher and Georges Desch{\^e}nes and Chantal Loirat and Marie-Christine Verpont and Michel Peuchmaur and Pierre Ronco and Renato C Monteiro and Elie Haddad},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 10},
  pages={2732-9}
}
Idiopathic nephrotic syndrome is characterized by glomerular proteinuria in the absence of infiltrating cells or immunoglobulin deposits. Although it is suspected that T cells secrete a circulating factor that leads to proteinuria by altering the permeability of the glomerular filtration barrier, the precise etiology of this syndrome is unknown. Because an animal model that mimics human idiopathic nephrotic syndrome does not exist, we developed a humanized mouse model of the disease by… CONTINUE READING

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DB: Transfer of a functional BASIC RESEARCH www.jasn.org 2738 Journal of the American Society of Nephrology

  • DE Mosier, RJ Gulizia, SM Baird, Wilson
  • J Am Soc Nephrol
  • 2007

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