A humanized monoclonal antibody that inhibits platelet‐surface ERp72 reveals a role for ERp72 in thrombosis

@inproceedings{Holbrook2018AHM,
  title={A humanized monoclonal antibody that inhibits platelet‐surface ERp72 reveals a role for ERp72 in thrombosis},
  author={L Holbrook and G. K. Sandhar and Parvathy Sasikumar and Michael P. Schenk and Alexander R. Stainer and K. A. Sahli and Gagan D. Flora and Andrew B. Bicknell and J. M. Gibbins},
  booktitle={Journal of thrombosis and haemostasis : JTH},
  year={2018}
}
Essentials ERp72 is a thiol isomerase enzyme. ERp72 levels increase at the platelet surface during platelet activation. We generated a humanized monoclonal antibody which blocks ERp72 enzyme activity (anti-ERp72). Anti-ERp72 inhibits platelet functional responses and thrombosis. SUMMARY Background Within the endoplasmic reticulum, thiol isomerase enzymes… CONTINUE READING