A humanized anti-M2 scFv shows protective in vitro activity against influenza.

@article{Gabbard2009AHA,
  title={A humanized anti-M2 scFv shows protective in vitro activity against influenza.},
  author={Jon D. Gabbard and Nileena Velappan and Roberto Di Niro and J{\"o}rg Schmidt and Carol A. Jones and Stephen M Tompkins and Andrew R. M. Bradbury},
  journal={Protein engineering, design & selection : PEDS},
  year={2009},
  volume={22 3},
  pages={189-98}
}
M2 is one of the most conserved influenza proteins, and has been widely prospected as a potential universal vaccine target, with protection predominantly mediated by antibodies. In this paper we describe the creation of a humanized single chain Fv from 14C2, a potent monoclonal antibody against M2. We show that the humanized scFv demonstrates similar… CONTINUE READING