A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts.

@article{Klein2013AHA,
  title={A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts.},
  author={Laura E Klein and Lingguang Cui and Zhenwei Gong and Kai Su and Radhika Muzumdar},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={440 2},
  pages={197-203}
}
A potent analog (HNG) of the endogenous peptide humanin protects against myocardial ischemia-reperfusion (MI-R) injury in vivo, decreasing infarct size and improving cardiac function. Since oxidative stress contributes to the damage from MI-R we tested the hypotheses that: (1) HNG offers cardioprotection through activation of antioxidant defense mechanisms leading to preservation of mitochondrial structure and that, (2) the activity of either of a pair of non-receptor tyrosine kinases, c-Abl… CONTINUE READING
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