A human whole blood model of LPS-mediated suppression of T cell activation.

@article{Yaqub2003AHW,
  title={A human whole blood model of LPS-mediated suppression of T cell activation.},
  author={Sheraz Yaqub and Vigdis Solhaug and Torkel Vang and Rigmor Solberg and Ansgar Oddne Aasen and Kjetil Task{\'e}n and Jacob E Wang},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2003},
  volume={9 3},
  pages={BR120-6}
}
BACKGROUND Lipopolysaccharide (LPS) is the main initiator of the early signaling events leading to sepsis caused by Gram-negative bacteria. Late stages of sepsis are associated with impairments of T lymphocyte function, a condition associated with nosocomial infection and poor outcome. The molecular basis for septic immunosuppression is not fully understood. MATERIAL/METHODS Human whole blood was incubated ex vivo with purified LPS. Cytokine responses and T cell proliferation were assessed… CONTINUE READING

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