A human trial of HSV-mediated gene transfer for the treatment of chronic pain

@article{Wolfe2009AHT,
  title={A human trial of HSV-mediated gene transfer for the treatment of chronic pain},
  author={Darren P Wolfe and Marina Mata and David J. Fink},
  journal={Gene Therapy},
  year={2009},
  volume={16},
  pages={455-460}
}
Gene transfer to the dorsal root ganglion using replication defective herpes simplex virus (HSV)-based vectors reduces pain-related behaviors in rodent models having inflammatory pain, neuropathic pain and pain caused by cancer in bone. HSV vectors engineered to produce inhibitory neurotransmitters, including the delta opioid agonist peptide enkephalin, the mu opioid agonist peptide endomorphin-2 and glutamic acid decarboxylase (GAD), to effect the release of gamma amino butyric acid (GABA) act… CONTINUE READING
BETA
Highly Cited
This paper has 41 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

HSV-mediated expression

  • S Hao, M Mata, JC Glorioso, DJ. Fink
  • 2007

Similar Papers

Loading similar papers…