A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system.

@article{Buzaska2009AHS,
  title={A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system.},
  author={Leonora Buzańska and Joanna Sypecka and Silvia Nerini-Molteni and Anna Compagnoni and Helena T. Hogberg and Riccardo del Torchio and Krystyna Domanska-Janik and Jens Zimmer and Sandra Coecke},
  journal={Stem cells},
  year={2009},
  volume={27 10},
  pages={2591-601}
}
The aim of our study was to investigate whether a human neural stem cell line derived from umbilical cord blood (HUCB-NSC) can serve as a reliable test model for developmental neurotoxicity (DNT). We assessed the sensitivity of HUCB-NSCs at different developmental stages to a panel of neurotoxic (sodium tellurite, methylmercury chloride, cadmium chloride, chlorpyrifos, and L-glutamate) and non-neurotoxic (acetaminophen, theophylline, and D-glutamate) compounds. In addition, we investigated the… CONTINUE READING

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