A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase.

@article{Xuan1994AHP,
  title={A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase.},
  author={Jim W. Xuan and Joe Kowalski and Ann F. Chambers and David T. Denhardt},
  journal={Genomics},
  year={1994},
  volume={20 1},
  pages={
          129-31
        }
}
A cDNA clone was isolated from HL60 human promyelocyte cells on the basis of the induction of its cognate mRNA by the phorbol ester TPA (12-O-tetradecanoyl phorbol-13-acetate) in the presence of cycloheximide. Northern analysis showed a peak of induction of a 1.9-kb mRNA at 3-6 h after TPA addition. Sequence analysis revealed that this cDNA was likely a human homolog of yeast isopentenyl diphosphate:dimethylallyl diphosphate isomerase, an enzyme important for isoprenoid synthesis and the… CONTINUE READING

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