A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation.

@article{Chen2008AHP,
  title={A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation.},
  author={Guoli Chen and Xiaoyang Zhou and Persoulla Nicolaou and Patricia L Rodr{\'i}guez and Guojie Song and Bryan A Mitton and Anand Pathak and Amit A Zachariah and Guo-Chang Fan and Gerald W. Dorn and Evangelia G Kranias},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2008},
  volume={22 6},
  pages={1790-6}
}
Aberrant beta-adrenergic signaling and depressed calcium homeostasis, associated with an imbalance of protein kinase A and phosphatase-1 activities, are hallmarks of heart failure. Phosphatase-1 is restrained by its endogenous inhibitor, protein phosphatase inhibitor-1 (PPI-1). We assessed 352 normal subjects, along with 959 patients with heart failure and identified a polymorphism in PPI-1 (G147D) exclusively in black subjects. To determine whether the G147D variant could affect cardiac… CONTINUE READING
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