A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol.

Abstract

Nine male and eight female healthy volunteers were exposed to 50 or 100 ppm trichloroethylene vapors for 4 h. Blood, urine, and exhaled breath samples were collected for development of a physiologically based pharmacokinetic (PBPK) model for trichloroethylene and its two major P450-mediated metabolites, trichloroacetic acid and free trichloroethanol. Blood… (More)

Topics

Cite this paper

@article{Fisher1998AHP, title={A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol.}, author={J W Fisher and Deirdre A. Mahle and Rasha Abbas}, journal={Toxicology and applied pharmacology}, year={1998}, volume={152 2}, pages={339-59} }