A human ovarian carcinoma murine xenograft model useful for preclinical trials.

  title={A human ovarian carcinoma murine xenograft model useful for preclinical trials.},
  author={John C. Elkas and Rae Lynn Baldwin and Mark Pegram and Yiou Tseng and Dennis Slamon and Beth Y. Karlan},
  journal={Gynecologic oncology},
  volume={87 2},
OBJECTIVE To establish a murine xenograft model of human ovarian carcinoma. METHODS A slurry of fresh human tumor from patients with intraperitoneal malignancies was heterotransplanted intraperitoneally into nude (nu/nu) and severely combined immunodeficient mice (CB-17, SCID). Xenograft growth was assessed by serial examination and necropsy. The xenografts were passaged to new animals when tumors were palpably greater than 1 cm(3). Histopathologic analysis of the xenografts was performed at… CONTINUE READING
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