A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

@article{MartnZanca1986AHO,
  title={A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences},
  author={Dionisio Mart{\'i}n-Zanca and Stephen H. Hughes and Mariano Barbacid},
  journal={Nature},
  year={1986},
  volume={319},
  pages={743-748}
}
A biologically active complementary DNA clone of a transforming gene present in a human colon carcinoma contains gene sequences of both tropomyosin and a previously unknown protein tyrosine kinase. The predicted protein (641 amino acids) encoded by this oncogene seems to have been formed by a somatic rearrangement that replaced the extracellular domain of a putative transmembrane receptor by the first 221 amino acids of a non-muscle tropomyosin molecule. 
ret transforming gene encodes a fusion protein homologous to tyrosine kinases.
TLDR
The ret transforming gene was activated by recombination between two unlinked segments of human DNA, most likely during transfection of NIH 3T3 cells, and encoded a fusion protein with a carboxy-terminal domain which is 40 to 50% homologous to members of the tyrosine kinase gene family.
ret transforming gene encodes a fusion protein homologous to tyrosine kinases
TLDR
The ret transforming gene was activated by recombination between two unlinked segments of human DNA, most likely during transfection of NIH 3T3 cells, and encoded a fusion protein with a carboxy-terminal domain which is 40 to 50% homologous to members of the tyrosine kinase gene family.
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase
Using a sensitive transfection-tumorigenicity assay, we have isolated a novel transforming gene from the DNA of two patients with chronic myelogenous leukemia. Sequence analysis indicates that the
A possible new member of tyrosine kinase family, human frt sequence, is highly conserved in vertebrates and located on human chromosome 13.
TLDR
A human genomic DNA (designated human frt) cross-hybridizing with the v-ros oncogene of UR2 sarcoma virus is isolated, which contains a 123-base-pair exon-like structure surrounded by consensus sequences of splice acceptor and donor sites.
Characterization of an activated human ros gene
TLDR
mcf3 probably arose during gene transfer from a normal human ros gene by the loss of a putative extracellular domain, and there do not appear to be any other gross rearrangements in the structure of mcf3.
A novel putative tyrosine kinase receptor encoded by the eph gene.
TLDR
The eph gene is overexpressed in several human carcinomas, suggesting that this gene may be involved in the neoplastic process of some tumors, and may define a new class of these molecules.
Molecular and biochemical characterization of the human trk proto-oncogene
TLDR
Results indicate that the product of the human trk locus is a novel tyrosine kinase cell surface receptor for an as yet unknown ligand.
A novel human gene closely related to the abl proto-oncogene.
TLDR
The detection of a novel 12-kb transcript by this gene in human normal and tumor cells establishes it as a new member of the tyrosine kinase family that is closely related to but distinct from c-abl.
Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene
Compared with normal erbB-2 gp185, mutant erbB-2 proteins generated by mutations either in the transmembrane domain or by NH2-terminal deletion are able to transform NIH 3T3 cells at a 10- to
Structure and transforming potential of the human cot oncogene encoding a putative protein kinase
TLDR
The cot oncogene was overexpressed in transformed SHOK cells and found to have a rearranged 3' end in the last coding exon, which probably resulted in a deletion and an altered C' terminus in the transforming protein.
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