A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions.

@article{Gupta2000AHN,
  title={A human nuclear shuttling protein that interacts with human immunodeficiency virus type 1 matrix is packaged into virions.},
  author={Kshitiz Gupta and David E. Ott and Thomas J Hope and Robert F. Siliciano and Jef D. Boeke},
  journal={Journal of virology},
  year={2000},
  volume={74 24},
  pages={11811-24}
}
Active nuclear import of the human immunodeficiency virus type 1 (HIV-1) preintegration complex (PIC) is essential for the productive infection of nondividing cells. Nuclear import of the PIC is mediated by the HIV-1 matrix protein, which also plays several critical roles during viral entry and possibly during virion production facilitating the export of Pr55(Gag) and genomic RNA. Using a yeast two-hybrid screen, we identified a novel human virion-associated matrix-interacting protein (VAN… CONTINUE READING

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