A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

@article{Cella2009AHN,
  title={A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity},
  author={Marina Cella and Anja G. Fuchs and William Vermi and Fabio F. Facchetti and Karel Otero and Jochen K Lennerz and Jason M. Doherty and Jason C. Mills and Marco Colonna},
  journal={Nature},
  year={2009},
  volume={457},
  pages={722-725}
}
Natural killer (NK) cells are classically viewed as lymphocytes that provide innate surveillance against virally infected cells and tumour cells through the release of cytolytic mediators and interferon (IFN)-γ. In humans, blood CD56dim NK cells specialize in the lysis of cell targets. In the lymph nodes, CD56bright NK cells secrete IFN-γ cooperating with dendritic cells and T cells in the generation of adaptive responses. Here we report the characterization of a human NK cell subset located in… CONTINUE READING
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