A human monoclonal antibody directed to blood group i antigen: heterohybridoma between human lymphocytes from regional lymph nodes of a lung cancer patient and mouse myeloma.

@article{Hirohashi1986AHM,
  title={A human monoclonal antibody directed to blood group i antigen: heterohybridoma between human lymphocytes from regional lymph nodes of a lung cancer patient and mouse myeloma.},
  author={Setsuo Hirohashi and Henrik Clausen and Edward Nudelman and Hiroyasu Inoue and Yukio Shimosato and Sen-itiroh Hakomori},
  journal={Journal of immunology},
  year={1986},
  volume={136 11},
  pages={4163-8}
}
A fusion of human lymphocytes released from regional lymph nodes of papillary adenocarcinoma of lung cancer with mouse myeloma P3-X63-Ag8-U1 cells resulted in a stable hybridoma-secreting human IgM antibody (NCC-1004) that reacts with a large proportion of squamous cell carcinomas of lung and esophagus as well as carcinoma of thyroid glands. However, the… CONTINUE READING