A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine.

@article{McCulloch2002AHM,
  title={A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine.},
  author={Vicki McCulloch and Bonnie L. Seidel-Rogol and Gerald S Shadel},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 4},
  pages={
          1116-25
        }
}
A critical step toward understanding mitochondrial genetics and its impact on human disease is to identify and characterize the full complement of nucleus-encoded factors required for mitochondrial gene expression and mitochondrial DNA (mtDNA) replication. Two factors required for transcription initiation from a human mitochondrial promoter are h-mtRNA polymerase and the DNA binding transcription factor, h-mtTFA. However, based on studies in model systems, the existence of a second human… CONTINUE READING

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