A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.

@article{Wang1993AHM,
  title={A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.},
  author={Ning Wang and Susan Gottesman and Mark C. Willingham and Michael M. Gottesman and Michael R. Maurizi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 23},
  pages={11247-51}
}
We have cloned a human ATP-dependent protease that is highly homologous to members of the bacterial Lon protease family. The cloned gene encodes a protein of 963 amino acids with a calculated molecular mass of 106 kDa, slightly higher than that observed by Western blotting the protein from human tissues and cell lines (100 kDa). A single species of mRNA was found for this Lon protease in all human tissues examined. The protease is encoded in the nucleus, and the amino-terminal portion of the… CONTINUE READING

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