A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

  title={A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.},
  author={Robert Rothlein and Michael L. Dustin and Steven D. Marlin and Timothy A Springer},
  journal={Journal of immunology},
  volume={137 4},
Homotypic adhesion by phorbol ester-stimulated lymphocytes requires LFA-1 and Mg+2 and does not involve like-like interactions between LFA-1 molecules on adjacent cells. The latter finding suggested that a second molecule, distinct from LFA-1, also participates in LFA-1-dependent adhesion. The identification of such a molecule was the object of this investigation. After immunization with LFA-1-deficient EBV-transformed lymphoblastoid cells, a MAb was obtained that inhibits phorbol ester… CONTINUE READING
Highly Influential
This paper has highly influenced 24 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 358 extracted citations


Publications referenced by this paper.
Showing 1-9 of 9 references

The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adheSpringer

  • New York, R London.P.559.Rothlein., T. A. Springer
  • 1986

Functional and structural interrelationshipsamong

  • A Springer.T., D. C. Anderson
  • 1985

Three distinct antigens associated with human T lymphocyte-mediated cytolysis: Barnstable

  • T. A. Springer.
  • C. J., W. F. Bodmer, G. Brown, G. Galfre. C…
  • 1982

Lymphocyte function-associated antigen 1 (LFA-I]: phocyte-mediated killing

  • Springer.
  • Proc. Natl. Acad. Sci. USA 78:4535. Springer. T.
  • 1981

Antibodies to major histocompatibility antigens produced by Sanchez-Madrid

  • C. Howard.
  • F., J. Nagy. E. Robbins, P. Simon,
  • 1977

A simplified method for cyanogen

  • P. Cuatrecasas
  • 1974

Similar Papers

Loading similar papers…