A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

@article{Blasina1999AHH,
  title={A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase},
  author={Alessandra Blasina and Inez van de Weyer and Marc Christiaan Laus and Walter Luyten and Andrew E. Parker and Clare H. McGowan},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={1-10}
}
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308 Citations

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A model wherein caffeine abrogates the G2/M checkpoint by targeting the ATM-Chk2/Cds1 pathway is proposed; by inhibiting ATM, it prevents the serine 216 phosphorylation of Cdc25C in the nucleus.
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It is shown that the G(2) DNA damage checkpoint simultaneously signals via both up-regulation of Wee1p and down- regulation of Cdc25p, thus providing a double-lock mechanism to ensure cell cycle arrest and genomic stability.
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