A human homolog of bacterial acetolactate synthase genes maps within the CADASIL critical region.

@article{Joutel1996AHH,
  title={A human homolog of bacterial acetolactate synthase genes maps within the CADASIL critical region.},
  author={Anne Joutel and Anne Ducros and S Alamowitch and Corinne Cruaud and Val{\'e}rie Domenga and Emmanuelle Mar{\'e}chal and Katayoun Vahedi and Hugues Chabriat and Marie Germaine Bousser and Elisabeth Tournier-Lasserve},
  journal={Genomics},
  year={1996},
  volume={38 2},
  pages={
          192-8
        }
}
CADASIL, a recently identified autosomal dominant condition characterized by the recurrence of subcortical infarcts leading to dementia, was previously mapped to chromosome 19p13.1 within a 2-cM interval, D19S226-D19S199. No recombination event was observed with D19S841, a highly polymorphic microsatellite marker isolated from a cosmid mapped to this region. We recently identified within this cosmid a conserved sequence that we used to screen a fetal brain cDNA library and isolated an… CONTINUE READING

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