A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.

@article{Tipnis2000AHH,
  title={A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.},
  author={Sarah R Tipnis and Nigel M Hooper and Russell Hyde and E Lorraine Karran and G. D. Christie and Anthony J. Turner},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 43},
  pages={33238-43}
}
A novel human zinc metalloprotease that has considerable homology to human angiotensin-converting enzyme (ACE) (40% identity and 61% similarity) has been identified. This metalloprotease (angiotensin-converting enzyme homolog (ACEH)) contains a single HEXXH zinc-binding domain and conserves other critical residues typical of the ACE family. The predicted protein sequence consists of 805 amino acids, including a potential 17-amino acid N-terminal signal peptide sequence and a putative C-terminal… CONTINUE READING
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