A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest.

@article{Gottwein2010AHH,
  title={A human herpesvirus microRNA inhibits p21 expression and attenuates p21-mediated cell cycle arrest.},
  author={Eva Gottwein and Bryan R Cullen},
  journal={Journal of virology},
  year={2010},
  volume={84 10},
  pages={5229-37}
}
The oncogenic human gammaherpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) expresses 12 viral microRNAs (miRNAs) in latently infected cells. Here, we report that cellular mRNAs encoding the cellular cyclin-dependent kinase inhibitor p21, a key inducer of cell cycle arrest, are direct targets for KSHV miR-K1. Ectopically expressed KSHV miR-K1 specifically inhibited the expression of endogenous p21 in KSHV-negative cells and strongly attenuated the cell cycle arrest that normally occurs… CONTINUE READING
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