A human hepatocellular in vitro model to investigate steatosis.

  title={A human hepatocellular in vitro model to investigate steatosis.},
  author={M. Jos{\'e} G{\'o}mez-lech{\'o}n and Mar{\'i}a Teresa Donato and Alicia Mart{\'i}nez-Romero and Nuria Jim{\'e}nez and Jose V Castell and Jos{\'e}-Enrique O'Connor},
  journal={Chemico-biological interactions},
  volume={165 2},
The present study was designed to define an experimental model of hepatocellular steatosis with a fat overaccumulation profile in which the metabolic and cytotoxic/apoptotic effects could be separated. This was accomplished by defining the experimental conditions of lipid exposure that lead to significant intracellular fat accumulation in the absence of overt cytotoxicity, therefore allowing to differentiate between cytotoxic and apoptotic effects. Palmitic (C16:0) and oleic (C18:1) acids are… CONTINUE READING
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