A human gene responsible for neurosensory, non-syndromic recessive deafness is a candidate homologue of the mouse sh-1 gene.

@article{Guilford1994AHG,
  title={A human gene responsible for neurosensory, non-syndromic recessive deafness is a candidate homologue of the mouse sh-1 gene.},
  author={Parry Guilford and Hammadi Ayadi and St{\'e}phane Blanchard and Hassan Chaib and Denis Le Paslier and Jean Weissenbach and Mohamed Mokthar Drira and Christine Petit},
  journal={Human molecular genetics},
  year={1994},
  volume={3 6},
  pages={989-93}
}
The identification of mouse models for the various forms of human neurosensory non-syndromic recessive deafness would constitute a major advance in the study of human deafness. Here we describe the localization of a human gene for neurosensory, nonsyndromic recessive deafness (NSRD2) to chromosome 11q13.5 by linkage analysis of a highly consanguineous family. A maximum lod score of 10.63 (theta = 0.018) was obtained for the microsatellite marker D11S527. Homozygosity mapping refined the… CONTINUE READING

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