A human functional protein interaction network and its application to cancer data analysis

@inproceedings{Wu2010AHF,
  title={A human functional protein interaction network and its application to cancer data analysis},
  author={Guanming Wu and Xin Feng and Lincoln D. Stein},
  booktitle={Genome Biology},
  year={2010}
}
One challenge facing biologists is to tease out useful information from massive data sets for further analysis. A pathway-based analysis may shed light by projecting candidate genes onto protein functional relationship networks. We are building such a pathway-based analysis system. We have constructed a protein functional interaction network by extending curated pathways with non-curated sources of information, including protein-protein interactions, gene coexpression, protein domain… CONTINUE READING
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