A human endometrial explant system: validation and potential applications.

@article{Dudley1992AHE,
  title={A human endometrial explant system: validation and potential applications.},
  author={Donald J. Dudley and Harry H. Hatasaka and D Ware Branch and Elizabeth H. Hammond and Murray D. Mitchell},
  journal={American journal of obstetrics and gynecology},
  year={1992},
  volume={167 6},
  pages={
          1774-80
        }
}
Critical evaluation of human endometrial explants as an ex vivo model system: a molecular approach.
TLDR
It is concluded that human endometrial explants are a complex model due to limited viability, difficult standardization and intrinsic alterations during culture.
Morphology of human endometrial explants and secretion of stromal marker proteins in short- and long-term cultures
TLDR
It is concluded that the explant culture model is viable for not more than 48 h in vitro for stromal cells, but that this interval can be prolonged by the addition of progesterone which initiates decidualisation.
Development of A 3D Tissue Slice Culture Model for the Study of Human Endometrial Repair and Regeneration
TLDR
A robust new method to study endometrial regeneration and differentiation processes using human endometrian tissue slice cultures incorporating an air-liquid interface into a 3D matrix scaffold of type I collagen gel, allowing sustained tissue viability over three weeks.
The effect of RU486 on the gene expression profile in an endometrial explant model.
TLDR
Results show that components of two important signalling pathways in endometrium-the JAK/STAT pathway, and the JNK pathway-are altered by RU486.
Amniotic Membrane as an in vitro Model for Endometrium- Extracellular Matrix Interactions
TLDR
An in vitro model to study the interaction between endometrial cells and extracellular matrix (ECM) and to evaluate the expression of cell adhesion molecules in endometrian cells and tissue fragments under in vitro conditions is developed.
TWEAK Appears as a Modulator of Endometrial IL-18 Related Cytotoxic Activity of Uterine Natural Killers
TLDR
In a pro-inflammatory environment (obtained by an excess of IL-18), inhibition of TWEAK was able to increase significantly NKp46 and TGF-beta1 mRNA expressions, and appears as a crucial physiological modulator to prevent endometrial uNK cytotoxicity in human.
Triphasic pattern in the ex vivo response of human proliferative phase endometrium to oestrogens
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