A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

@article{Taniguchi1996AHC,
  title={A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.},
  author={K Taniguchi and M Wada and K Kohno and T Nakamura and T Kawabe and M Kawakami and K Kagotani and K Okumura and S Akiyama and M Kuwano},
  journal={Cancer research},
  year={1996},
  volume={56 18},
  pages={4124-9}
}
  • K Taniguchi, M Wada, +7 authors M Kuwano
  • Published 1996 in Cancer research
By targeting the ATP binding conserved domain in three ATP binding cassette superfamily proteins (P-glycoprotein, multidrug resistance protein, and cystic fibrosis transmembrane regulator), we isolated the cDNA of a new ATP binding cassette superfamily that was specifically enhanced in a cisplatin-resistant human head and neck cancer KB cell line. A human clone homologous to rat canalicular multispecific organic anion transporter (cMOAT) was found and designated human cMOAT. Fluorescence in… CONTINUE READING
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