A human breast cancer model for the study of telomerase inhibitors based on a new biotinylated-primer extension assay


SummaryTelomerase is an RNA-dependent polymerase that synthesizes telomeric DNA (TTAGGG)n repeats. The overall goal of our work was to establish human cancer models that can be used to design clinical trials with telomerase inhibitors. The objectives of this study were (1) to set up a human breast cancer system that allows evaluation of the effects of… (More)
DOI: 10.1038/sj.bjc.6690526


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