A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers.

@article{Morinaga1991AHA,
  title={A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers.},
  author={Tomonori Morinaga and Hiroshi Yasuda and Takashi Hashimoto and Kanji Higashio and T. Tamaoki},
  journal={Molecular and cellular biology},
  year={1991},
  volume={11 12},
  pages={6041-9}
}
We have isolated a full-length cDNA encoding a protein (ATBF1) that binds to an AT-rich motif in the human alpha-fetoprotein gene enhancer. The amino acid sequence deduced from the cDNA revealed that this is the largest DNA-binding protein (306 kDa) known to date, containing four homeodomains, 17 zinc finger motifs, and a number of segments potentially involved in transcriptional regulation. Although the exact function of this protein has not been determined, these structural features suggest… CONTINUE READING

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